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BIONi037-A-2 Gene-edited iPSC line

Donor information


Disease status


Disease: normal

Disease/phenotype related genetic modifications

Disease: Alzheimer's disease
Type of modification: Isogenic
Gene: ApoE
Chromosome location: 19q13.32
Nucleotide sequence HGSV: NM_000041.3:c.526C>T
Protein sequence HGSV: NP_000032.1:p.Arg176Cys
Zygosity: Homozygous
Target locus modification: Changed
Description: BIONi037-A-2 ApoE2/E2 is an isogenic mutant of BIONi037-A (ApoE3/E3); The genotype at base position described by rs7412 has been modified in the subclone from C/C to T/T, which changes aa from Arg to Cys. This then defines a ApoE2/E2 genotype in the subclone. Please see chromatogram for confirmation of the base changes in the subclone.

General information

Cell line name:BIONi037-A-2
Cell line alternative names:BIONi037-A ApoE2/2 #M10-7
Biosamples ID:SAMEA104235612
hPSCreg name:BIONi037-A-2
Derivation country:Denmark

Related lines

Derived from: BIONi037-A
All subclones of BIONi037-A: BIONi037-A-1, BIONi037-A-2, BIONi037-A-3, BIONi037-A-4
This line is part of a set of isogenic APOE lines based on the iPS cell line BIONi037-A. The set comprises the following APOE genotypes: • BIONi037-A-1 (APOE KO) • BIONi037-A-2 (APOE 2/2) • BIONi037-A (APOE 3/3) • BIONi037-A-3 (APOE 3/4) • BIONi037-A-4 (APOE 4/4) A DNA SNP array revealed no larger chromosomal aberrations to be reported. Other isogenic ApoE cell line cohorts are also available, generated from BIONi010-C, UKBi011-A and STBci006-A.
At European Collection of Authenticated Cell Cultures (ECACC)
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