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BIONi037-A-1 Gene-edited iPSC line

Donor information


Disease status


Disease: normal

Disease/phenotype related genetic modifications

Disease: Alzheimer's disease
Type of modification: Gene knock-out
Gene: ApoE
Chromosome location: 19q13.32
Delivery method: CRISPR-associated (CRISPR/Cas) System
Description: The ApoE gene is knocked out in this line; deletion of the ApoE gene by insertion of a frame shift in exon 1. The target locus has been mutated.

General information

Cell line name:BIONi037-A-1
Cell line alternative names:16423 ApoE KO
Biosamples ID:SAMEA104026332
hPSCreg name:BIONi037-A-1
Derivation country:Denmark

Related lines

Derived from: BIONi037-A
All subclones of BIONi037-A: BIONi037-A-1, BIONi037-A-2, BIONi037-A-3, BIONi037-A-4
This line is part of a set of isogenic APOE lines based on the iPS cell line BIONi037-A. The set comprises the following APOE genotypes: • BIONi037-A-1 (APOE KO) • BIONi037-A-2 (APOE 2/2) • BIONi037-A (APOE 3/3) • BIONi037-A-3 (APOE 3/4) • BIONi037-A-4 (APOE 4/4) A DNA SNP array revealed no larger chromosomal aberrations to be reported. Other isogenic ApoE cell line cohorts are also available, generated from BIONi010-C, UKBi011-A and STBci006-A.
At European Collection of Authenticated Cell Cultures (ECACC)
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